{"id":415,"date":"2026-04-10T16:48:17","date_gmt":"2026-04-10T16:48:17","guid":{"rendered":"https:\/\/firebrick-hamster-619463.hostingersite.com\/?post_type=product&#038;p=415"},"modified":"2026-08-18T12:57:31","modified_gmt":"2026-08-18T12:57:31","slug":"igf-1-lr3","status":"publish","type":"product","link":"https:\/\/aestx-systems.com\/en\/product\/igf-1-lr3\/","title":{"rendered":"IGF-1 LR3"},"content":{"rendered":"<p><strong>IGF-1 LR3 (Insulin-like Growth Factor-1 Long R3)<\/strong> is a synthetic long-chain variant of human IGF-1 in which glutamic acid at position 3 is replaced by arginine and a 13-amino-acid N-terminal peptide is added. This modification substantially reduces its binding affinity for IGF-binding proteins (IGFBPs), allowing prolonged bioavailability in in vitro systems.<\/p>\n<h2>Research areas for IGF-1 LR3<\/h2>\n<h3>Cell proliferation &amp; growth signalling pathways<\/h3>\n<p>IGF-1 LR3 is used in cell culture studies to examine PI3K\/Akt\/mTOR signalling cascades and their role in cell proliferation and survival.<\/p>\n<h3>Muscle cell biology<\/h3>\n<p>Studied in myocyte cultures in relation to protein synthesis regulation and hypertrophy signalling at the cellular level.<\/p>\n<h3>IGFBP interaction research<\/h3>\n<p>Its reduced IGFBP binding makes it a valuable tool for in vitro models requiring free IGF-1 signalling without interference from carrier proteins.<\/p>\n<p><em>Anecdotal note: Reports from the research community describe strong interest in anabolic signalling pathways. These reports are not scientifically substantiated, do not constitute claims of efficacy and relate exclusively to research settings.<\/em><\/p>\n<h2>AESTX Systems quality standards<\/h2>\n<ul>\n<li>Purity \u226599% \u2014 verified by HPLC<\/li>\n<li>Certificate of analysis (COA) available<\/li>\n<li>Form: lyophilised powder \u2014 laboratory quality<\/li>\n<li>Fast &amp; discreet shipping from Germany (Germany &amp; EU)<\/li>\n<\/ul>\n<h2>Laboratory use &amp; handling (research purposes)<\/h2>\n<p>Lyophilised powder for reconstitution under laboratory conditions. For use by qualified personnel only.<\/p>\n<hr>\n<h2>Buy IGF-1 LR3 from AESTX Systems<\/h2>\n<p>Looking to <strong>buy IGF-1 LR3<\/strong>? AESTX Systems supplies the peptide <strong>IGF-1 LR3<\/strong> (Long R3 IGF-1) as a lab-tested reference material with an HPLC-confirmed purity of <strong>\u2265 99 %<\/strong>, exclusively for research and laboratory use.<\/p>\n<h3>Why choose IGF-1 LR3 from AESTX Systems?<\/h3>\n<ul>\n<li><strong>\u226599% purity<\/strong> \u2014 every batch analysed by HPLC and LC-MS for purity and identity<\/li>\n<li><strong>Batch-specific COA<\/strong> \u2014 Certificate of Analysis with every delivery<\/li>\n<li><strong>Shipping from Germany<\/strong> \u2014 fast, discreet delivery within Germany and to Austria<\/li>\n<li><strong>Research Use Only<\/strong> \u2014 appropriate declaration as a reference material<\/li>\n<\/ul>\n<p>This allows research and educational institutions to obtain <strong>IGF-1 LR3 in Germany<\/strong> easily as a reference material. All purity and batch information can be traced through the accompanying COA.<\/p>\n<h3>IGF-1 LR3 in cell research<\/h3>\n<p>IGF-1 LR3 (Long R3 IGF-1) is a modified variant of insulin-like growth factor 1 with reduced binding to IGF-binding proteins. It is studied in relation to PI3K\/Akt signalling pathway activation and cell proliferation models.<\/p>\n<h3>Research into growth factor signalling pathways<\/h3>\n<p>In vitro models examine IGF-1 LR3 in relation to its prolonged half-life and activation of IGF-1 receptors in cell cultures. As a high-purity reference substance with \u226599% HPLC purity, it is used to characterise growth factor-mediated mechanisms. Each batch is supplied with a batch-specific Certificate of Analysis.<\/p>\n<h3>Quality, specifications and storage<\/h3>\n<p>Research and educational institutions looking to obtain <strong>IGF-1 LR3 in Germany<\/strong> as a reference material receive consistently documented quality from AESTX Systems. Purity of \u226599% is determined using high-performance liquid chromatography (HPLC); identity and molecular weight are analytically confirmed. In research practice, the lyophilised material is described as being stored in a cool, dry place protected from light; after reconstitution, it is refrigerated. All purity, batch and specification information can be traced through the accompanying COA.<\/p>\n<h3>Frequently asked questions about buying IGF-1 LR3<\/h3>\n<p><strong>What is the purity of IGF-1 LR3 from AESTX Systems?<\/strong><br \/>The IGF-1 LR3 offered has an HPLC-confirmed purity of \u226599% and is supplied with a batch-specific Certificate of Analysis.<\/p>\n<p><strong>Are products shipped from Germany?<\/strong><br \/>Yes. IGF-1 LR3 is shipped quickly and discreetly from Germany to destinations within Germany and Austria.<\/p>\n<p><strong>Who is the product intended for?<\/strong><br \/>IGF-1 LR3 is intended exclusively for research and laboratory use by qualified research and educational institutions and appropriately knowledgeable individuals.<\/p>\n<p><em><strong>Research disclaimer:<\/strong> This product is intended exclusively for research and laboratory use (in vitro). It is not intended for human or animal use and is not a medicine, food or cosmetic. It is not intended to diagnose, treat, cure or prevent disease and does not replace medical advice. Purchase is restricted to qualified research and educational institutions and appropriately knowledgeable individuals.<\/em><\/p>\n<h2>Buy IGF-1 LR3 \u2014 analytically tested research quality<\/h2>\n<p>IGF-1 LR3 (Long R3 insulin-like growth factor 1) is a synthetic analogue of insulin-like growth factor 1 with an extended amino acid sequence. Its Arg3 substitution and N-terminal extension result in substantially weaker binding to IGF-binding proteins than native IGF-1. In cell culture and in vitro models, this leads to greater free availability and longer stability in experimental media. This makes LR3 the most commonly used IGF-1 variant in research.<\/p>\n<h3>IGF-1 vs IGF-1 LR3 \u2014 the difference for research<\/h3>\n<p>Native IGF-1 is rapidly bound by binding proteins in experimental media. The LR3 variant was specifically developed to reduce this binding, remaining freely available for longer in experimental systems. Specifying the variant used is therefore essential in comparative studies.<\/p>\n<h3>Quality, purity and storage<\/h3>\n<p>Each batch of our IGF-1 LR3 is tested by HPLC (purity \u226599%) and LC-MS (identity). The corresponding Certificate of Analysis is available through our <a href=\"https:\/\/aestx-systems.com\/en\/laboranalysen\/\">Lab analyses<\/a> page. In lyophilised form, the peptide is stable over the long term at \u221220 \u00b0C; after reconstitution, short-term refrigerated storage is recommended. The solvent used for reconstitution is <a href=\"https:\/\/aestx-systems.com\/en\/product\/bac-mischwasser\/\">bacteriostatic water (BAC water)<\/a>.<\/p>\n<p><em>Research Use Only \u2014 not intended for human use.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p><strong>IGF-1 LR3<\/strong> \u2013 Long-R3-Variante des IGF-1 mit reduzierter IGFBP-Bindung f\u00fcr PI3K\/Akt\/mTOR-Signalwegforschung. HPLC-gepr\u00fcfte Reinheit \u2265 99 %, mit COA. Nur f\u00fcr Forschungszwecke \u2013 Versand aus Deutschland.<\/p>","protected":false},"featured_media":497,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[26,24,108],"product_tag":[],"class_list":["post-415","product","type-product","status-publish","has-post-thumbnail","product_cat-99-purity","product_cat-peptide","product_cat-wachstum-performance","first","instock","sale","shipping-taxable","purchasable","product-type-variable","has-default-attributes"],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/aestx-systems.com\/en\/wp-json\/wp\/v2\/product\/415","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/aestx-systems.com\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/aestx-systems.com\/en\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/aestx-systems.com\/en\/wp-json\/wp\/v2\/comments?post=415"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/aestx-systems.com\/en\/wp-json\/wp\/v2\/media\/497"}],"wp:attachment":[{"href":"https:\/\/aestx-systems.com\/en\/wp-json\/wp\/v2\/media?parent=415"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/aestx-systems.com\/en\/wp-json\/wp\/v2\/product_brand?post=415"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/aestx-systems.com\/en\/wp-json\/wp\/v2\/product_cat?post=415"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/aestx-systems.com\/en\/wp-json\/wp\/v2\/product_tag?post=415"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}