AHK-Cu

AHK-Cu (copper tripeptide-3) is a synthetic tripeptide with the sequence alanyl-L-histidyl-L-lysine, which complexes a copper ion (Cu²⁺) with high affinity. AHK-Cu is closely related to naturally occurring GHK-Cu and differs structurally only by replacing glycine with alanine at the first position. This small change shifts its research profile towards hair follicle biology and makes AHK-Cu one of the most targeted copper peptides in follicular research.

Research areas for AHK-Cu (copper tripeptide-3)

Hair follicle & anagen research

The scientific focus of AHK-Cu is the biology of dermal papilla cells, the control centres at the base of each hair follicle. In vitro models investigate how AHK-Cu affects proliferation of these cells and prolongation of the anagen (growth) phase.

Collagen synthesis & tissue matrix

Like other copper peptides, AHK-Cu is studied in relation to type I and type III collagen synthesis in dermal fibroblast cultures. The copper ion acts as a cofactor for enzymes such as lysyl oxidase, which are relevant to extracellular matrix cross-linking.

Angiogenic processes

AHK-Cu is studied in relation to new blood vessel formation (angiogenesis). Model studies examine its potential influence on expression of vascular endothelial growth factor (VEGF), which modulates the blood supply to tissues such as skin and hair follicles.

Oxidative stress & antioxidant enzymes

Through its copper binding, AHK-Cu is studied as a modulator of copper-dependent enzymes such as superoxide dismutase. This research area examines the peptide’s role in limiting oxidative stress in cellular models.

Note: the research areas listed relate exclusively to preclinical laboratory research. No effects in humans are claimed.

AESTX Systems quality standards

• Purity ≥99% (HPLC verified)
• Identity confirmed by mass spectrometry
• Batch-specific Certificate of Analysis (COA)
• Lyophilised powder, packaged for laboratory use

Laboratory use & handling (research purposes)

AHK-Cu is supplied as lyophilised powder and is not ready to use. For research purposes, it is usually reconstituted with bacteriostatic water. Before reconstitution, store in a cool place protected from light; after reconstitution, refrigerate. Handling is restricted to trained laboratory personnel.

Buy AHK-Cu from AESTX Systems

AHK-Cu complements our copper peptide range as the hair-focused counterpart to GHK-Cu. For laboratories focused on follicle biology, AHK-Cu offers a clearly defined research profile with consistently high specifications.

Why choose AHK-Cu from AESTX Systems?

• Purity ≥99% with a batch-specific Certificate of Analysis
• Targeted research profile in hair follicles & the dermal papilla
• Consistent specifications across all batches
• Discreet shipping and packaging suitable for laboratory use

AHK-Cu in follicular research

AHK-Cu has primarily been described in hair research, whereas GHK-Cu has a broader focus. Its synthetic origin enables reproducible specifications, which are advantageous for comparative in vitro studies in dermal papilla cells.

Research into regenerative mechanisms

The combination of a small tripeptide structure and stable copper complexation makes AHK-Cu an interesting tool for investigating copper-dependent signalling and enzyme pathways in tissue models.

Quality, specifications and storage

AHK-Cu is supplied as lyophilised powder with a purity of ≥99% and should be stored in a cool place protected from light.

Frequently asked questions about buying AHK-Cu

How does AHK-Cu differ from GHK-Cu?
AHK-Cu uses alanine instead of glycine at the first position and is primarily used in hair follicle research, while GHK-Cu covers a broader range.

In what form is AHK-Cu supplied?
As lyophilised powder with a purity of ≥99% and a batch-specific Certificate of Analysis.

Is AHK-Cu ready to use?
No. AHK-Cu is intended exclusively for laboratory research and must be properly reconstituted before use.

Research peptide — exclusively for laboratory research. Not intended for human consumption or therapeutic use.